Abstract

Professor Alexander Yu. Prosekov is a prominent scientist in food and agricultural biotechnology, a academician of the Russian Academy of Sciences, and a Doctor of Science in Biology and Engineering. In 2008, he was awarded the Russian Federation Government Prize in Science and Technology for Young Scientists. This review highlights his extensive contributions to innovative food technologies and functional foods. Carrying forward Professor L. A. Ostroumov’s scientific school, which received a 2020 Presidential Grant for the support of leading national research schools (NSh-2694.2020.4), Professor Prosekov has supervised 44 PhD and 15 Doctoral theses. His students follow an integrated approach to biotechnological challenges, developing novel methods for bioactive substance recovery and advanced biomedicines. Their research significantly contributes to national food security, sustainable production, and food innovation. Under Professor Prosekov’s leadership, his research school continues to advance the frontiers of biotechnology and the food industry, ensuring the quality and safety of domestic products.

Keywords

A. Yu. Prosekov, academician of the Russian Academy of Sciences, Russian Government Prize in Science and Technology, scientific school, biotechnology, food technology

References

1. Dolganyuk V, Sukhikh S, Kalashnikova O, Ivanova S, Kashirskikh E, et al. Food proteins: Potential resources. Sustainability. 2023;15:5863. https://doi.org/10.3390/su15075863
2. Sukhikh S, Ivanova S, Dolganyuk V, Pilevinova I, Prosekov A, et al. Evaluation of the prospects for the use of microalgae in functional bread production. Applied Sciences. 20 22;12:12563. https://doi.org/10.3390/app122412563
3. Vesnina A, Prosekov A, Kozlova O, Atuchin V. Genes and eating preferences, their roles in personalized nutrition. Genes. 2020;11(4):357. https://doi.org/10.3390/genes110403574
4. Ponasenko A, Sinitsky M, Minina V, Vesnina A, Khutornaya M, et al. Immune response and lipid metabolism gene polymorphisms are associated with the risk of obesity in middle-aged and elderly patients. Journal of Personalized Medicine. 2022;12:238. https://doi.org/10.3390/jpm12020238
5. Babich OO, Pokrovsky VS, Anisimova NY, Sokolov NN, Prosekov AY. Recombinant L-phenylalanine ammonia lyase from Rhodosporidium toruloides as a potential anticancer agent. Biotechnology and Applied Biochemistry. 2013;60(3):316–322. https://doi.org/10.1002/bab.1089
6. Mahan KC, Gandhi MA, Anand S. Pegvaliase: A novel treatment option for adults with phenylketonuria. Current Medical Research and Opinion. 2019;35(4):647–651. https://doi.org/10.1080/03007995.2018.1528215
7. Babich O, Dyshlyuk L, Prosekov A, Noskova S, Ivina O, Pavsky V, et al. Study of the potential of the capsule shell based on natural polysaccharides in targeted delivery of the L-phenylalanine ammonia-lyase enzyme preparation. Pharmaceuticals. 2020;13(4):63. https://doi.org/10.3390/ph13040063
8. Babich O, Dyshlyuk L, Noskova S, Prosekov A, Ivanova S, et al. The effectiveness of plant hydrocolloids at maintaining the quality characteristics of the encapsulated form of L-phenylalanine-ammonia-lyase. Heliyon. 2020;6(1):e03096. https://doi.org/10.1016/j.heliyon.2019.e03096
9. Soboleva OA, Minina VI, Torgunakova AV, Titov RA, Yakovleva AA, et al. Vitamin D status in connection with VDR and GC genes polymorphism in coal mining workers. Problems of Nutrition. 2024;93(4):74–83. (In Russ.) https://doi.org/10.33029/0042-8833-2024-93-4-74-83
10. Timofeeva AA, Minin AV, Bakanova ML, Zakharova YaS, Torgunakova AV, et al. Polymorphism of genes encoding DNA repair enzymes in coal mine workers with lung cancer. Journal of Siberian Federal University – Biology. 2024;17(1):33–44. (In Russ.) https://elibrary.ru/SPGETQ
11. Yakovleva AA, Minina VI, Soboleva OA, Borisova OI, Bulatova OV, et al. Influence of ApoE gene polymorphism on development of obesity and blood biochemical parameters in coal mine workers. Gigiena and Sanitariya. 2025;104(3):318–322. (In Russ.) https://doi.org/10.47470/0016-9900-2025-104-3-318-322
12. Prosekov AYu, Vesnina AD, Lyubimova NA, Chekushkina DYu, Mikhailova ES. Consumer genomics in personalized nutrition. Food Processing: Techniques and Technology. 2025;55(2):400–415. (In Russ.) https://doi.org/10.21603/2074-9414-2025-2-2582
13. Vesnina A, Prosekov A, Atuchin V, Minina V, Ponasenko A. Tackling atherosclerosis via selected nutrition. International Journal of Molecular Sciences. 2022;23(15):8233. https://doi.org/10.3390/ijms23158233
14. Chekushkina D, Kozlova O, Vechtomova E, Prosekov A. Dietary use of Hericium coralloides for NAFLD prevention. Nutrients. 2026;18(3):418. https://doi.org/10.3390/nu18030418
15. Vesnina A, Kozlova O, Ivanova S, Prosekov A. Citric acid cycle genes and nutrigenetics. International Journal of Molecular Sciences. 2026;27(5):2360. https://doi.org/10.3390/ijms27052360
16. Babich O, Prosekov A, Zaushintsena A, Sukhikh A, Dyshlyuk L, et al. Identification and quantification of phenolic compounds of Western Siberia Astragalus danicus in different regions. Heliyon. 2019;5(8):e02245. https://doi.org/10.1016/j.heliyon.2019.e02245
17. Babich O, Sukhikh S, Prosekov A, Asyakina L, Ivanova S. Medicinal plants to strengthen immunity during a Pandemic. Pharmaceuticals. 2020;13:313. https://doi.org/10.3390/ph13100313
18. Sukhikh S, Babich O, Prosekov A, Patyukov N, Ivanova S. Future of chondroprotectors in the treatment of degenerative processes of connective tissue. Pharmaceuticals. 2020;13: 220. https://doi.org/10.3390/ph13090220
19. Sukhikh S, Babich O, Prosekov A, Kalashnikova O, Noskova S, et al. Antidiabetic properties of plant secondary metabolites. Metabolites. 2023;13:513. https://doi.org/10.3390/metabo13040513
20. Vesnina A, Le V, Ivanova S, Prosekov A. Antidiabetic potential of mangiferin: An in silico and in vivo approach. Pharmaceutics. 2025;17:1262. https://doi.org/10.3390/pharmaceutics17101262
21. Vesnina A, Milentyeva I, Minina V, Kozlova O, Asyakina L. Evaluation of the in vivo anti-atherosclerotic activity of quercetin isolated from the hairy roots of Hedysarum neglectum Ledeb. Life. 2023;13:1706. https://doi.org/10.3390/life13081706
22. Dmitrieva A, Kozlova O, Atuchin V, Milentieva I, Vesnina A, et al. Study of the effect of baicalin from Scutellaria baicalensis on the gastrointestinal tract normoflora and Helicobacter pylori. International Journal of Molecular Sciences. 2023;24:11906. https://doi.org/10.3390/ijms241511906
23. Babich O, Sukhikh S, Pungin A, Ivanova S, Asyakina L, et al. Modern trends in the in vitro production and use of callus, suspension cells and root cultures of medicinal plants. Molecules. 2020;25:5805. https://doi.org/10.3390/molecules25245805
24. Asyakina L, Sukhikh S, Ivanova S, Prosekov A, Ulrikh E, et al. Determination of the qualitative composition of biologically-active substances of extracts of in vitro callus, cell suspension, and root cultures of the medicinal plant Rhodiola rosea. Biomolecules. 2021;11:365. https://doi.org/10.3390/biom11030365
25. Asyakina L, Ivanova S, Prosekov A, Dyshlyuk L, Chupakhin E, et al. Determination of the qualitative composition of biologically active substances of extracts of in vitro callus, cell suspension, and root cultures of the medicinal plant Rhaponticum carthamoides. Applied Sciences. 2021;11:2555. https://doi.org/10.3390/app11062555
26. Babich O, Sukhikh S, Pungin A, Astahova L, Chupakhin E, et al. Evaluation of the conditions for the cultivation of callus cultures of Hyssopus officinalis regarding the yield of polyphenolic compounds. Plants. 2021;10:915. https://doi.org/10.3390/plants10050915
27. Sukhikh S, Ivanova S, Babich O, Larina V, Krol O, et al. Antimicrobial screening and fungicidal properties of Eucalyptus globulus ultrasonic extracts. Plants. 2022;11:1441. https://doi.org/10.3390/plants11111441
28. Le V, Dolganyuk V, Sukhikh A, Babich O, Ivanova S, et al. Phytochemical analysis of Symphytum officinale root culture extract. Applied Sciences. 2021;11:4478. https://doi.org/10.3390/app11104478
29. Le V, Sukhikh A, Larichev T, Ivanova S, Prosekov A, et al. Isolation of the main biologically active substances and phytochemical analysis of Ginkgo biloba callus culture extracts. Molecules. 2023;28:1560. https://doi.org/10.3390/molecules28041560
30. Milentyeva IS, Fedorova AM, Larichev TA, Altshuler OG. Biologically active compounds in Scutellaria baicalensis L. callus extract: Phytochemical analysis and isolation. Foods and Raw Materials. 2023;11(1):172–186. https://doi.org/10.21603/2308-4057-2023-1-564
31. Vesnina AD, Milentyeva IS, Le VM, Fedorova AM, Altshuler OG, et al. Quercetin isolated from Hedysarum neglectum Ledeb. as a preventer of metabolic diseases. Foods and Raw Materials. 2025;13(1):192–201. https://doi.org/10.21603/2308-4057-2025-1-633
32. Velichkovich NS, Dunchenko NI, Stepanova AA, Kozlova OV, Faskhutdinova ER, Yustratov VP, et al. The phytochemical composition of Kuzbass medicinal plants. Foods and Raw Materials. 2025;13(2):219–232. https://doi.org/10.21603/2308-4057-2025-2-649
33. Chekushkina DYu, Fedorova AM, Kovalenko SV, Milentyeva IS, Altshuler OG, et al. Anti-metabolic syndrome effect of trans-cinnamic acid. Food Processing: Techniques and Technology. 2025;55(1):136–147. https://doi.org/10.21603/2074-9414-2025-1-2563
34. Fedorova AM, Shevel AA, Kovalenko SV, Miller ES, Loseva AI, et al. Geroprotective potential of Thymus vulgaris L. callus culture and its metabolites. Foods and Raw Materials. 2026;14(2):443–460. https://doi.org/10.21603/2308-4057-2026-2-688
35. Babich O, Sukhikh S, Larina V, Kalashnikova O, Kashirskikh E, et al. Algae: Study of edible and biologically active fractions, their properties and applications. Plants. 20 22;11:780. https://doi.org/10.3390/plants11060780
36. Dolganyuk V, Belova D, Babich O, Prosekov A, Ivanova S, et al. Microalgae: A promising source of valuable bioproducts. Biomolecules. 2020;10:1153. https://doi.org/10.3390/biom10081153
37. Dolganyuk V, Andreeva A, Budenkova E, Sukhikh S, Babich O, et al. Study of morphological features and determination of the fatty acid composition of the microalgae lipid complex. Biomolecules. 2020;10(11):1571. https://doi.org/10.3390/biom10111571
38. Andreeva A, Budenkova E, Babich O, Sukhikh S, Ulrikh E, et al. Production, purification, and study of the amino acid composition of microalgae proteins. Molecules. 2021;26:276 7. https://doi.org/10.3390/molecules26092767
39. Sukhikh S, Prosekov A, Ivanova S, Maslennikov P, Andreeva A, et al. Identification of metabolites with antibacterial activities by analyzing the FTIR spectra of microalgae. Life. 2 022;12:1395. https://doi.org/10.3390/life12091395
40. Dolganyuk V, Andreeva A, Sukhikh S, Kashirskikh E, Prosekov A, et al. Study of the physicochemical and biological properties of the lipid complex of marine microalgae isolated from the coastal areas of the eastern water area of the Baltic sea. Molecules. 2022;27:5871. https://doi.org/10.3390/molecules27185871
41. Babich O, Budenkova E, Kashirskikh E, Dolganyuk V, Ivanova S, et al. Study of the polysaccharide production by the microalga Vischeria punctata in relation to cultivation conditions. Life. 2022;12:1614. https://doi.org/10.3390/life12101614
42. Dolganyuk VF, Sukhikh SA, Kashirskih EV, Ulrikh EV, Kremleva OE, Babich OO. Screening and profiling the antioxidant properties of psychrophilic microalgae and cyanobacteria from the baltic sea. Food Processing: Techniques and Technology. 2024;54(2):212–221. (In Russ.) https://doi.org/10.21603/2074-9414-2024-2-2501
43. Chizhova AA, Babich OO, Kashirskikh EV, Budenkova EA, Dyshlyuk LS. Microalgae Scenedesmus as a source of pigments and other biologically active metabolites: Application prospects and problems. Food Processing: Techniques and Technology. 2025;55(3):468–484. (In Russ.) https://doi.org/10.21603/2074-9414-2025-3-2585
44. Dolganyuk VF, Kashirskikh EV, Sukhikh SA, Kremleva OE, Ulrikh EV, et al. Effect of cultivation conditions on polysaccharide synthesis by Skeletonema pseudocostatum. Foods and Raw Materials. 2026;14(2): 276–284. https://doi.org/10.21603/2308-4057-2026-2-671
45. Babich O, Sukhikh S, Dyshlyuk L, Shishko O, Milentyeva I, et al. Evaluation of biocompatibility and antagonistic properties of microorganisms isolated from natural sources for obtaining biofertilizers using microalgae hydrolysate. Microorganisms. 2021;9:1667. https://doi.org/10.3390/microorganisms9081667
46. Zimina M, Babich O, Prosekov A, Sukhikh S, Ivanova S, et al. Overview of global trends in classification, methods of preparation and application of bacteriocins. Antibiotics. 20 20;9:553. https://doi.org/10.3390/antibiotics9090553
47. Sukhikh S, Kalashnikova O, Ivanova S, Prosekov A, Krol O, et al. Evaluating the influence of microbial fermentation on the nutritional value of soybean meal. Fermentation. 2022;8: 458. https://doi.org/10.3390/fermentation8090458
48. Ivanova S, Prosekov A. Study of the antioxidant potential of UV-treated vegetables. Nutraceuticals. 2022;2(4):289–299. https://doi.org/10.3390/nutraceuticals2040022
49. Prosekov AYu, Ivanova SA. Food security: The challenge of the present. Geoforum. 2018;91:73–77. https://doi.org/10.1016/j.geoforum.2018.02.030
50. Prosekov AYu. Food security and globalization. Foods and Raw Materials. 2025;14(2):247–251. https://doi.org/10.21603/2308-4057-2026-2-679
51. Prosekov AYu, Ivanova SA. Nutritional features of indigenous peoples of Siberia and North America: Are we relatives? Journal of Ethnic Foods. 2018;5(3):155–160. https://doi.org/10.1016/j.jef.2018.07.002
52. Prosekov AYu, Kagan ES, Meshechkin VV. Modeling elk population in the Kemerovo Region. Bulletin of Hunting. 2020;17(2):100–106. (In Russ.) https://elibrary.ru/ZMSDXU
53. Prosekov AYu. Characteristics and key limitations of traditional methods for accounting hunting animals and digital technologies for solving the existing problems (review). Agricultural Science Euro-North-East. 2020;21(4):341–354. (In Russ.) https://doi.org/10.30766/2072-9081.2020.21.4.341-354
54. Prosekov AYu. Introduction of digital technologies in methods of accounting for hunting animals. Proceedings of Lower Volga Agro-University Complex: Science and Higher Education. 2020;3(3):268–274. (In Russ.) https://doi.org/10.32786/2071-9485-2020-03-28
55. Prosekov AYu, Boyko EV. Hunting management of the Kemerovo region – Kuzbass. Scientific Life. 2021;16(1):127–138. (In Russ.) https://doi.org/10.35679/1991-9476-2021-16-1-127-138
56. Prosekov A, Kuznetsov A, Rada A, Ivanova S. Methods for monitoring large terrestrial animals in the wild. Forests. 2020;11(8):808. https://doi.org/10.3390/f11080808
57. Ivanova S, Prosekov A, Kaledin A. Is ecotourism an opportunity for large wild animals to thrive? Sustainability. 2022;14:2718. https://doi.org/10.3390/su14052718
58. Ivanova S, Prosekov A, Kaledin A. A survey on monitoring of wild animals during fires using drones. Fire. 2022;5:60. https://doi.org/10.3390/fire5030060
59. Ivanova S, Prosekov A. Hunting resource management by population size control by remote sensing using an unmanned aerial vehicle. Nature Environment and Pollution Technology. 2024;23(1):391–399. https://doi.org/10.46488/NEPT.2024.v23i01.033
60. Lisina N, Ushakova A, Ivanova S, Prosekov A. Regulation of interaction between hunters and land users: A comparative legal study. Law. 2023;12:14. https://doi.org/10.3390/laws12010014
61. Ivanova S, Vesnina A, Fotina N, Prosekov A. An overview of carbon footprint of coal mining to curtail greenhouse gas emissions. Sustainability. 2022;14:15135. https://doi.org/10.3390/su142215135
62. Ivanova S, Zhidkova E, Prosekov A. Limiting the carbon footprint of an enterprise: Calculation methods and solutions. Qubahan Academic Journal. 2023;3(4):51–61. https://doi.org/10.48161/qaj.v3n4a158
63. Ivanova S, Vesnina A, Fotina N, Prosekov A. Approaches to reducing the carbon footprint of mines within the framework of planned biorecultivation of technogenically disturbed lands. International Journal of Chemical and Biochemical Sciences. 2024;25(19):629–639. https://doi.org/10.62877/72-IJCBS-24-25-19-72
64. Ivanova S, Vesnina A, Fotina N, Prosekov A. Phytoremediation of technogenically disturbed soils of coal mines. International Journal of Chemical and Biochemical Sciences. 2024;25(19):610–621. https://doi.org/10.62877/70-IJCBS-24-25-19-70
65. Ivanova S, Vesnina A, Fotina N, Prosekov A. Technogenically disturbed lands of coal mines: Restoration methods. Nature Environment and Pollution Technology. 2024;23(4):2447–24 52. https://doi.org/10.46488/NEPT.2024.v23i01.033
66. Ivanova S, Vesnina A, Fotina N, Prosekov A. Influence of coal mining activities on soil’s agrochemical and biochemical properties. Qubahan Academic Journal. 2023;3(4):387–39 9. https://doi.org/10.58429/qaj.v3n4a22961
67. Atuchin VV, Asyakina LK, Serazetdinova YR, Frolova AS, Velichkovich NS, et al. Microorganisms for bioremediation of soils contaminated with heavy metals. Microorganisms. 2023;11(4):864. https://doi.org/10.3390/microorganisms11040864
68. Asyakina LK, Vorob'eva EE, Proskuryakova LA, Zharko MYu. Evaluating extremophilic microorganisms in industrial regions. Foods and Raw Materials. 2023;11(1):162–171. https://doi.org/10.21603/2308-4057-2023-1-556
69. Ivanova LA, Prosekov AYu, Ivanov PP, Mikhyalova ES, Timoshchuk IV, et al. Assessment of the efficiency of wastewater treatment from coal enterprises for suspended solids using various filtering materials. Mining Science and Technology Russian Federation. 2024;9(3):263–270. https://doi.org/10.17073/2500-0632-2024-03-227
70. Prosekov AYu, Timoshchuk IV, Gorelkina AK, Mikhailova ES, Golubeva NS, et al. Comparative assessment of the content of pollutants in quarry wastewater of Kuzbass coal enterprises. Coal. 2023;8(4):69–73. (In Russ.) https://doi.org/10.18796/0041-5790-2023-4-69-73
71. Ivanova LA, Golubeva NS, Timoshchuk IV, Gorelkina AK, Prosekov AYu, et al. Evaluation of the efficiency of wastewater treatment of a coal mining enterprise and its impact on the pollution of small rivers. Ecology and Industry of Russia. 2023;27(1):60–65. (In Russ.) https://doi.org/10.18412/1816-0395-2023-1-60-65
72. Ivanova LA, Timoshchuk IV, Gorelkina AK, Mikhaylova ES, Golubeva NS, Neverov EN, et al. Removing excess iron from sewage and natural waters: Selecting optimal sorbent. Food Processing: Techniques and Technology. 2024;54(2):398–411. (In Russ.) https://doi.org/10.21603/2074-9414-2024-2-2516
73. Neverov EN, Timoshchuk IV, Gorelkina AK, Ivanova LA, Mikhaylova ES, et al. Removal of manganese ions from natural and wastewater. Food Processing: Techniques and Technology. 2025;55(3):634–647. (In Russ.) https://doi.org/10.21603/2074-9414-2025-3-2598